The purpose of this article is to advance a new understanding of gender as a routine accomplishment embedded in everyday interaction. To do so entails a critical assessment of existing perspectives on sex and gender and the introduction of important distinctions among sex, sex category, and gender. We argue that recognition of the analytical independence of these concepts is essential for understanding the interactional work involved in being a gendered person in society. The thrust of our remarks is toward theoretical (...) reconceptualization, but we consider fruitful directions for empirical research that are indicated by our formulation. (shrink)

In the Platonic work Alcibiades I, a divinely guided Socrates adopts the guise of a lover in order to divert Alcibiades from an unthinking political career. The contributors to this carefully focussed volume cover aspects of the background to the work; its arguments and the philosophical issues it raises; its relationship to other Platonic texts, and its subsequent history up to the time of the Neoplatonists. Despite its ancient prominence, the authorship of Alcibiades I is still unsettled; the essays and (...) two appendices, one historical and one stylometric, come together to suggest answers to this tantalising question. (shrink)

Using data from American emergency call centers, this article focuses on the coordination, and mutual relevance, of participants’ effort to manage two forms of unit completion – sequence closing and concluding the occasion in which the project was pursued. In doing so, we specify the import of sequence organization as one method for conducting, organizing, and resolving interactional projects participants may be said to pursue, and describe a range of possible relations between project completion and occasion closure and the locations (...) from which problems come to be introduced as parties move to resolve projects and close calls. As we show, sequence and occasion closings produced in the service of projects are fateful: they inexorably demand that the participants arrive at some alignment – or make visible their failure to do so – regarding the projects pursued in it, the status of those projects, and thus who, as a consequence, the parties are for another, that is, their ‘identities’. For strangers and familiars both, the management of projects and the manner in which closing is achieved matters. (shrink)

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? The processes that occur along the way are so complex that any attempt to understand development necessitates a multi-disciplinary approach, integrating data from cognitive studies, computational work, and neuroimaging - an approach till now seldom taken in the study of child development. Neuroconstructivism is a major new 2 volume publication that seeks to redress this balance, presenting an integrative new framework for (...) considering development. In the first volume, the authors review up-to-to date findings from neurobiology, brain imaging, child development, computer and robotic modelling to consider why children's thinking develops the way it does. They propose a new synthesis of development that is based on 5 key principles found to operate at many levels of descriptions. They use these principles to explain what causes a number of key developmental phenomena, including infants' interacting with objects, early social cognitive interactions, and the causes of dyslexia. The "neuroconstructivist" framework also shows how developmental disorders do not arise from selective damage to normal cognitive systems, but instead arise from developmental processes that operate under atypical constraints. How these principles work is illustrated in several case studies ranging from perceptual to social and reading development. Finally, the authors use neuroimaging, behavioural analyses, computational simulations and robotic models to provide a way of understanding the mechanisms and processes that cause development to occur. Computer and robotic models provide concrete tools for investigating the processes and mechanisms involved in learning and development. Volume 2 illustrates the principles of 'Neuroconstructivist' development, with contributions from 9 different labs across the world. Each of the contributions illustrates how models play a central role in understanding development. The models presented include standard connectionist neural network models as well as multi-agent models. Also included are robotic models emphasizing the need to take embodiment and brain-system interactions seriously. A model of Autism and one of Specific Language Impairment also illustrate how atypical development can be understood in terms of the typical processes of development but operating under restricted conditions. This volume complements Volume 1 by providing concrete examples of how the 'Neuroconstructivist' principles can be grounded within a diverse range of domains, thereby shaping the research agenda in those domains. (shrink)

Endothelial cells line the inside of all blood vessels, forming a structurally and functionally heterogenous population of cells. Their complexity and diversity has long been recognized, yet very little is known about the molecules and regulatory mechanisms that mediate the heterogeneity of different endothelial cell populations. The constitutive organ‐ and microenvironment‐specific phenotype of endothelial cells controls internal body compartmentation, regulating the trafficking of circulating cells to distinct vascular beds. In contrast, surface molecules associated with the activated cytokine‐inducible endothelial phenotype play (...) a critical role in pathological conditions including inflammation, tumor angiogenesis, and wound healing. Differentiation of the endothelial cell phenotypes appears to follow similar mechanisms to the differentiation of hematopoietic cells, with the exception that endothelial cells maintain transdifferentiating competence. The present review offers a scheme of endothelial cell differentially expressed endothelial cell molecules as targets for directed therapeutic intervention. (shrink)

Each contributor to this book has used personal experience as the basis from which to frame his individual sociological perspectives. Because they have personalized their work, their accounts are real, and recognizable as having come from 'real' persons, about 'real' experiences. There are no objectively-distanced disembodied third person entities in these accounts. These writers are actual people whose stories will make you laugh, cry, think, and want to know more.

The monumental works of Bertrand Russell and Louis Couturat have set a firm pattern of interpretation which many follow in their approach to the Philosophy of Leibniz. In the Preface to the second edition of The Philosophy of Leibniz , Russell reaffirms his contention that “Leibniz’s philosophy was almost entirely derived from his logic”. He welcomes the support provided in Couturat’s La Logique de Leibniz . Russell remarks “No candid reader—can doubt that Leibniz’s metaphysic was derived by him from the (...) subject-predicate logic. This appears, for example, from the paper ‘Primae Veritates’ where all the main doctrines of the Monadology are deduced, with terse logical rigor from the premises; ‘Always therefore the predicate or consequent adheres in the subject or antecedent, and in this fact consists the nature of truth in general—But this is true in every affirmative truth, universal or singular, necessary or contingent’.” Referring further to Couturat, he points out that in his book the “Principle of Sufficient Reason” and “The Identity of Indiscernibles” are “expressly deduced—from the analytic character of all true propositions”. In short, Russell is contending that in formulating his metaphysics Leibniz used the rigorous methods of deductive logic and employed “models” drawn from logic to construct his “picture of reality”, i.e. his metaphysics. (shrink)

There is little to indicate from, her circumstances that events would propel Helga Wanglie, an 86-year-old Minneapolis woman, into the center of public controversy. We know little of her life prior to the events that removed her from the world of conscious, sentient beings. By the time of her death on 4 July 1991, Mrs. Wanglie had become the focus of a nationwide public and professional debate on the rights of a patient in a persistent vegetative state to receive aggressive (...) medical treatment when such treatment is felt by the patient's doctors not to be in the patient's best interests. (shrink)

Assisted suicide is a tragic issue, one of those for which the tools of mere logic are inadequate and in which the power of the individual case is compelling and seductive but not necessarily clarifying. Meaningful dialogue is difficult. Persuasion is limited because the resolution of the issue, on a moral level, must be founded upon fundamental notions of what it means to be human, especially in the midst of suffering or disability or at the point of death.

He further argues that it is necessary to rethink traditional conceptions of argument, and to find a position that avoids the limitations of both the highly abstract approach of formal logic and the highly contextualized approaches of rhetoric and communication theory.".

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? Neuroconstructivism is a pioneering 2 volume work that sets out a whole new framework for considering the complex topic of development, integrating data from cognitive studies, computational work, and neuroimaging.

The dominant notions of consciousness in the West are anchored in a peculiar matrix of dissociated sensibility held in place by unthematized body practices. It is misleading to evaluate spiritual and philosophical notions of consciousness simply from the point of view of verbal, logical analysis, when they are expressions of these deeply rooted experiential sensibilities, deliberately cultivated over long years of habituation. There is a dramatic difference between how the West thinks of body practices as irrelevant to analyzing states of (...) consciousness and how other cultures make direct links between these practices and the shaping of consciousness. For at least the last 150 years in Europe and the United States a number of teachers have developed body practices in deliberate resistance to the dualistic structurings of mentalities and physicality. They constitute a cultural movement of resistance shaped by the recognition of the mistaken notions embodied in Western dualism. An example is given of the work of Bonnie Bainbridge Cohen, the creator of the School of Body‐Mind Centering. Key Words: Embodiment, Somatics, Cultivation, Practices, Dualism. (shrink)